Exogenous Metabolite Analysis Service

Exogenous metabolites refer to foreign chemical substances, which may be toxic or harmless. These exogenous metabolites include not only drugs but also dietary supplements, food additives, and environmental pollutants. When exogenous metabolites significantly disrupt the metabolism and transport of endogenous compounds into the body, they can be harmful to the human body. Exogenous metabolites can be directly metabolized by metabolic enzymes in the body. Studying how exogenous metabolites undergo metabolism in the human body helps accelerate drug discovery and toxicology research. In drug discovery, understanding drug metabolites aids in the study of drug mechanisms of action. Additionally, metabolism can cause adverse side effects, so understanding the metabolism of various chemicals is also crucial in the field of toxicology. Metabolomics is a comprehensive analysis of small molecules and is an ideal tool for systematically analyzing endogenous metabolites. Metabolomics has many applications in the study of xenobiotics, such as acetaminophen (APAP) metabolism, cyclophosphamide (CP), and ifosfamide (IF) metabolism.

Metabolic reactions of cyclophosphamide

BiotechPack Biotechnology, relying on advanced analytical platforms and professional analysts and technicians, provides exogenous metabolite analysis, metabolite screening, and exogenous metabolite/metabolite concentration monitoring services. We possess various high-throughput analytical technologies for exogenous metabolite metabolomics, such as ultra-high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry (UPLC-ESI-QTOFMS), gas chromatography-mass spectrometry (GC-MS), and nuclear magnetic resonance (NMR), among others. For subsequent analyses, we offer multivariate data analysis, including but not limited to principal component analysis (PCA), partial least squares discriminant analysis (PLS-DA), and orthogonal projections to latent structures discriminant analysis (OPLS-DA).

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Untargeted metabolomics
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Metabolomics