Molecular Size Variability Analysis Based on CE-SDS
The aggregation or fragmentation of protein molecules is the main cause of molecular size variants, which can directly affect the bioactivity, stability, and safety and efficacy of proteins as drugs. During the development and production of biological drugs, even minor molecular size variations may lead to reduced efficacy or potential safety risks. Therefore, accurately detecting and analyzing molecular size variants is a necessary step in the characterization of biological products. Capillary Electrophoresis-Sodium Dodecyl Sulfate (CE-SDS) technology utilizes an electric field to cause charged particles to migrate in a capillary, thereby achieving the separation and identification of proteins or peptides. When combined with the surfactant SDS, proteins become negatively charged, allowing them to be sorted by molecular size.CE-SDS combines the high efficiency of electrophoretic separation with the accurate measurement of protein molecular size from SDS-PAGE,allowing for the analysis of both single protein samples and complex protein mixtures.
BTP's CE-SDS based analysis of molecular size variants
CE-SDS based molecular size variant analysis offers high resolution, sensitivity, and a high degree of automation, making it widely applicable in fields such as protein purity analysis, determination of protein molecular size, detection of protein aggregation or fragmentation, disease diagnosis, and biopharmaceuticals. It holds significant value for new drug development, protein function research, and quality control in biopharmaceuticals.Biotyech Park (BTP)has obtainedCNAS/ISO9001 dual quality system certification; the companyhas established comprehensive physical and chemical analysis and structural characterization platforms capable of separating and fully characterizing molecular size variants. Whether you are interested in protein fragments, conjugates, or aggregates, BTP can provide precise, efficient, and comprehensive solutions. Feel free to contact us for more details!
Bilingual Project Report in Chinese/English
In the technical report, Biotyech Park will provide you with a detailed bilingual technical report in Chinese and English, including:
1. Experimental Procedures (Chinese and English)
2. RelevantExperimentalParameters (Chinese and English)
3. Detailed information on CE-SDS based molecular size variant analysisDetailed Information
4. ElectrophoresisImages
5. Raw Data
CE-SDS based molecular size variant analysisOne-stop Service
Simply place an order and send the samples
Biotyech Park's one-stop service covers: sample processing - machine analysis - data analysis - project report
Related Services
Product-related Impurity Analysis
Other Process-related Impurity Analysis
Protein Molecular Weight Determination
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