Charge Heterogeneity Analysis Based on cIEF
Charge heterogeneity is a key attribute of biological macromolecules such as antibodies, enzymes, and proteins. It affects the stability, solubility, and biological activity of the molecules..Deamidation, oxidation, glycosylation, glycation, changes at the N- or C-terminus, loss of tertiary structure, or reduction of disulfide bonds can all cause changes in charge heterogeneity.Due to the direct or indirect impact of charge heterogeneity on the efficacy and safety of biological macromolecules, its analysis holds an important position in the research and production of biopharmaceuticals.
Capillary Isoelectric Focusing (cIEF) is an advanced technique specifically used for analyzing charge heterogeneity., which uses a capillary as a medium, creating a pH gradient and applying an electric field to allow protein or peptide molecules to migrate to their isoelectric points, thereby achieving precise analysis of charge heterogeneity..cIEF is widely applied in isoelectric point analysis, charge heterogeneity analysis, and protein modification research due to its high efficiency and high-resolution capabilities in analyzing protein charge heterogeneity.
BTP-based cIEF charge heterogeneity analysis
Biotech Park (BTP) has been certified with dual quality systems CNAS/ISO9001.; the company has established a platform for the separation and comprehensive characterization of charge variants, providing you with comprehensive and precise cIEF charge heterogeneity analysis services. Whether you are interested in trace charge variants or need comprehensive analysis of the entire molecular population, BTP can offer solutions to meet your needs. Free consultation is welcome!
Bilingual Project Report
In the technical report, Biotech Park provides you with a detailed bilingual (Chinese and English) technical report, which includes:
1. Experimental procedures (in Chinese and English)
2. Related experimental parameters (in Chinese and English)
3. Detailed information on cIEF-based charge heterogeneity analysis
4. Electrophoresis images
5. Raw data
cIEF-based charge heterogeneity analysisOne-stop Service
You only need to place an order and send your samples.
Biotech Park's one-stop service completes: sample processing, on-machine analysis, data analysis, project report.
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