PROTAC Drug Off-Target Analysis
Proteolysis-targeting chimera (PROTAC)drugis anew type of drug, which combines protein degradation technology and chimera technology,can ubiquitinate target proteins through the Ubiquitin-Proteasome System (UPS), thereby inhibiting tumor growth. Unlike traditional small molecule inhibitors, PROTAC drugs not only block protein function but completely degrade it. Off-target effects refer to the interaction of drugs with proteins other than the intended targets, which may lead to adverse reactions or other unexpected consequences. For PROTAC drugs, off-target analysis is crucial because they may cause unintended protein degradation, resulting in adverse biological effects.
TypicalPROTAC drugstructural diagram
PROTAC drug off-target analysis utilizes the UPSsystemto degrade target proteins,canbe used to evaluate the effects and impacts of drugs on sites other than the intended targets within the body,assistingin guidingandadjusting drug design and dosage to minimize off-target effects and enhance therapeutic efficacy. Biotech company Biotage uses Thermo's Orbitrap Fusion Lumos mass spectrometer combined with Nano-LC nanoliter chromatography technology,to establish an efficientPROTAC drug off-targetanalysis platform. Mass spectrometry technology can identify and quantify proteins and other biomolecules in complex samples, thereby detecting and analyzing other proteins that may interact with PROTAC drugs.Feel free to contact us for a free consultation to learn more details!
Chinese/English project report
In the technical report, Biotage provides you with a detailed bilingual technical report in both Chinese and English, including:
1. Experimental procedures (in Chinese and English)
2. Relevant mass spectrometry parameters (in Chinese and English)
3. Detailed information on PROTAC drug off-target analysis
4. Mass spectrometry images
5. Raw data
PROTAC drug off-target analysisone-stop service
You only need to place an order and send samples
Biotage's one-stop service completes: sample processing, machine analysis, data analysis, project report
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