Post-translational modification proteomics and metabolomics integration analysis

Post Translational Modifications (PTMs) of proteins are covalent processing events that proteins undergo during or after translation. The post-translationally modified proteome refers to the overall level of post-translationally modified proteins in cells or tissues. Currently, known protein post-translational modifications mainly include glycosylation, phosphorylation, acylation, ubiquitination, disulfide bond pairing, methylation, and nitrosylation, among others. The metabolome is the overall level of small molecules (commonly referred to as metabolites) within cells, tissues, or organisms. Post-translationally modified proteins can regulate cellular biological processes and affect changes in the body's metabolism. Metabolism-affecting post-translationally modified proteins include not only post-translationally modified transcription factors but also post-translationally modified metabolic enzymes. Therefore, integrating analysis of post-translationally modified proteomes and metabolomes, and comparing their expression differences, is conducive to analyzing biological metabolic mechanisms from different perspectives, exploring differential modified proteins, metabolites, and the important pathways and related genes they participate in, for further in-depth research.

BaiTai Pack Biotechnology utilizes Thermo Fisher's Orbitrap Fusion Lumos mass spectrometry platform combined with nanoLC-MS/MS nanoscale chromatography to provide identification services for post-translational modifications such as phosphorylation/glycosylation/ubiquitination/acylation/methylation/disulfide bonds/nitrosylation, targeted and untargeted metabolomics analysis services for various samples, and integrates customizable bioinformatics analysis methods to offer mass spectrometry-based integrated analysis services of post-translationally modified proteomes and metabolomes for researchers.

Integrative Analysis Workflow of Post-Translationally Modified Proteomes and Metabolomes

Integrative Analysis Workflow of Post-Translationally Modified Proteomes and Metabolomes

Application Fields

Agriculture and Forestry: Mechanisms of stress resistance, species conservation research, etc.;
Animal Husbandry: Pathogenic mechanisms research, meat and dairy product quality studies, etc.;
Marine Fisheries: Fisheries environment and seafood safety, etc.;
Microbiology: Pathogenic mechanisms, drug resistance mechanisms, pathogen-host interaction research, etc.;
Biomedicine: Biomarkers, disease mechanisms, disease classification, drug development, personalized treatment, etc.;
Environmental Science: Optimization of fermentation processes, biofuel production, environmental hazard risk assessment research, etc.;
Food Science: Optimization of food storage and processing conditions, identification of food components and quality, food safety monitoring, etc.

Bilingual Project Reports in Chinese/English

In the technical report, BaiTai Pack will provide you with a detailed bilingual technical report in Chinese/English, including:

1. Experimental procedures (in Chinese and English)
2. Relevant experimental parameters (in Chinese and English)
3. Mass spectrometry images
4. Raw data
5. Results of modified proteomes and metabolomes

Related Services

Integrative Analysis of Proteomics and Metabolomics
Integrative Analysis of Transcriptomics and Metabolomics
Analysis of Post-Translationally Modified Proteomes
Proteomics
Metabolomics