Should S1P focus on metabolomics or lipidomics?
S1P (Sphingosine-1-phosphate) is a sphingolipid metabolite and a key signaling molecule in the sphingolipid metabolic pathway, characterized by its lipid properties. Therefore, from the perspective of analytical methods and metabolic pathway classification:
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Categorically, S1P is more appropriately included in the field of 'lipidomics' research;
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In terms of methodology, lipidomics often employs targeted or untargeted LC-MS/MS methods, particularly using reverse-phase chromatography (RP-LC) combined with ESI positive ion mode MRM or PRM methods, which can detect S1P with high sensitivity;
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For data interpretation, if the research focuses on the sphingolipid metabolic pathway (such as the metabolic conversion between S1P, Sphingosine, and Ceramide), lipidomics databases (like LIPID MAPS) and pathway tools (such as KEGG sphingolipid metabolism) should be used for annotation and pathway enrichment analysis.
If the research emphasis is on signal transduction functions or interactions with non-lipid molecules, it can also be analyzed as a specific metabolite within targeted metabolomics. However, from a methodological and categorical standpoint, it is recommended to conduct detection and interpretation using a lipidomics approach.
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