Plasma Proteomics
The plasma proteome is the most complex human proteome, related to almost all cells, tissues, and organs. Plasma proteomics research helps to discover disease-related biomarkers. Biotec Packard Biotechnology provides mass spectrometry-based plasma proteomics analysis services.
Plasma proteomics refers to the study of proteins in plasma at a holistic level. The plasma proteome is the most complex human proteome. Plasma contains approximately 92% water, 7% protein, and 1% other substances. Proteins in plasma include those that maintain the body's normal physiological state and low-abundance proteins secreted, leaked, or shed under various pathological and physiological states. Among these low-abundance proteins are critical proteins for signaling and regulation, whose level changes are related to various diseases. However, quantitatively, a small number of high-abundance proteins account for more than 90% of the total plasma protein content. These high-abundance proteins include albumin, IgG, and proteases. High-abundance proteins in plasma often interfere with the detection of low-abundance proteins, so the first step in plasma proteomics research is to remove high-abundance proteins.
Plasma Proteomics
In recent years, more and more technologies have been used to remove high-abundance proteins from plasma. However, there is no single technology that can solve all protein purification problems. Therefore, the current general strategy is to use an optimized combination of several different separation and purification technologies for the removal of high-abundance proteins. Selective separation of high-abundance proteins using affinity columns is the current main method, which includes antibody-based affinity methods and dye-based affinity methods, many of which have been commercialized.
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