What are the reasons for irregular baseline noise during high-performance liquid chromatography analysis?
1. Check for leakage; 2. Contamination, degradation of the mobile phase, or preparation using low-quality solvents; 3. Incompatibility of solvents in the mobile phase; 4. Issues with detector/recorder electronic components; 5. Presence of bubbles in the system; 6. Bubbles in the detector; 7. Contamination of the flow cell (even minimal contamination can cause noise); 8. Insufficient detector lamp energy; 9. Loss or blockage of chromatographic column packing; 10. Uneven mixing of the mobile phase or malfunctioning mixer.
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