Can detergents be used during sample preparation? Can the facility remove detergents?
Almost all detergents used for biological applications are incompatible with mass spectrometry. This includes Triton, Tween, NP-40, and Brij. For a fee, we can remove some common detergents at low concentrations from samples. However, we will completely reject samples containing certain detergents. If you are looking for a detergent compatible with mass spectrometry, you may consider Waters RapiGest or sodium deoxycholate (SDC), which can be acid-precipitated and centrifugally separated from the sample. These are merely suggestions, and we cannot guarantee their effectiveness for your application.
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