High-Resolution Liquid Chromatography Mass Spectrometry Molecular Weight Testing

Molecular weight is the sum of the relative atomic masses of the atoms constituting a compound's molecule, serving as a fundamental characteristic parameter for compounds, playing a crucial role in the identification and verification of various compounds. The molecular weight of proteins is a key characteristic parameter in determining the quality of protein products. Common methods for determining protein molecular weight include SDS-PAGE gel electrophoresis, viscosity method, gel permeation chromatography (GPC), light scattering method, and mass spectrometry-based methods. High-resolution liquid mass spectrometry for molecular weight determination utilizes high-resolution liquid chromatography-tandem mass spectrometry to identify the relative molecular weight of compounds. The liquid chromatography-mass spectrometry (LC-MS) technique combines the separation function of chromatography with the identification function of mass spectrometry, enabling molecular weight identification of complex mixed samples. Common types of mass spectrometers used in LC-MS molecular weight analysis include electrospray ionization mass spectrometry (ESI-MS) and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS).

Based on MALDI-TOF-MS and ESI-MS high-resolution mass spectrometry systems combined with Nano-LC chromatography, Biotech Pack provides efficient and accurateprotein molecular weight LC-MS analysis
packages, applicable for molecular weight determination of various protein samples, meeting diverse protein molecular weight analysis needs including peptide fingerprinting and protein identification. Free consultation available.

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