Linear Ion Trap Orbitrap Mass Spectrometry (LTQ-Orbitrap MS)

The hybrid linear ion trap Orbitrap mass spectrometer is one of the hybrid instruments based on Fourier transform. The first mass analyzer is a linear ion trap (LIT), and the second is a high-resolution Orbitrap. Since LIT itself is a detector, the LIT-Orbitrap combination can be used for MS and MSn experiments.

To utilize the highest resolution of the Orbitrap analyzer, the data acquisition time of both the LIT and FT analyzers must be considered. The ion capture capability and the high data acquisition speed of the LIT allow for the collection of MS/MS spectra of selected precursor ions, while transferring part of the precursor to the Orbitrap for precise mass measurement. Different collision methods can be used in the second collision cell at different collision energies for additional dissociation. Products from either collision cell are injected into the Orbitrap through the C-trap, and transient signals are collected in the Orbitrap for subsequent FT analysis.

Linear ion trap Orbitrap hybrid mass spectrometer

The significant advantages of this hybrid mass spectrometer make it popular in the following research areas:

Proteomics:Top-down analysis, protein identification, post-translational modification (PTM) analysis, and quantitative proteomics

Metabolomics:Untargeted metabolomics, de novo structural elucidation of unknown compounds

Biotech company Biotech Pack uses the Orbitrap Elite hybrid ion trap Orbitrap mass spectrometer to provide you with professional analytical services. We can also customize related analytical services according to your specific needs. Feel free to contact us!

Related services

Proteomics
Post-translational modification (PTM) analysis
Quantitative proteomics
Top-down protein sequencing analysis
Top-down proteomics
Untargeted metabolomics
Metabolomics