Antibody Drug HDX Hydrogen-Deuterium Exchange

AntibodyDrugis a type of drug that uses artificially synthesized antibodies to treat diseases by specifically binding to target molecules to achieve therapeutic effects. Commonantibodydrug types include monoclonal antibodies, artificially synthesized antibody fragments, immunotoxins, and antibody-drug conjugates.Antibodydrugs have shown significant efficacy in treating various diseases, such as cancer, autoimmune diseases, inflammatory diseases, immune regulation, and ophthalmic diseases.

Hydrogen deuterium exchange mass spectrometry (HDX MS) is a mass spectrometry technique used to study the spatial conformation of proteins. This technology can be used to infer protein epitope conformation. In addition, HDX MS can be used to study dynamic changes in protein structure, protein-protein interaction sites, and identify protein surface active sites. HDX MS enables rapid studies of amino acid sequences located on the protein surface of native proteins in solution, thus having widespread applications in studying dynamic protein epitope activity sites.

BiologicalProductCharacterization HDX Hydrogen-Deuterium ExchangeAnalysisSchematicDiagram

BotaiparkBiotechnology(BTP), adoptsISO9001certified quality control system to manage laboratories and has obtained nationalCNASlaboratory accreditation, providing customers with drug quality research services compliant with global pharmaceutical regulations.Weuse the advanced Waters nanoACQUITY UPLC HD-Exchange System, combined withsub-2-micron column packing material, which significantly shortens the liquid phase analysis time without compromising chromatographic separation efficiency, offering ultra-high separation capability. Additionally, BotaiparkBiotechnologyutilizes online automated sample preparation integrated with high-resolution mass spectrometry, ensuring the reliability of experimental data and improving experimental efficiency, fully guaranteeing the effectiveness of sample preparation and the reliability of identification results.

Botaipark BiotechnologyAntibodyDrug Characterization Content