Phosphorylated Proteomics
Phosphoproteomics is a science that specifically studies phosphorylated proteins, including qualitative and quantitative analysis of phosphorylated proteins at the omics level. Biotech company Biotyper providesphosphorylation quantitative proteomics researchservices.
Phosphoproteomics
Phosphorylation is one of the most common types of post-translational modifications of proteins and is a key regulatory modification form in biology. In the life cycle of mammalian cells, at least one-third of proteins undergo phosphorylation modifications. Protein phosphorylation is carried out by protein kinases that transfer phosphate groups from ATP or GTP molecules to specific amino acid side chains in substrate proteins. Protein phosphorylation is involved in many signal transduction pathways and cellular metabolic processes, and many known diseases are also associated with abnormal protein phosphorylation. Therefore, exploring which proteins, what types, and at which sites phosphorylation occurs under different physiological or pathological states helps to elucidate the essence of life activities and the mechanisms of disease occurrence. Phosphoproteomics involves studying phosphorylated proteins at the omics level.
Phosphorylation Quantitative Proteomics
Phosphorylation quantitative proteomics refers to the study of quantitative proteomics of phosphorylated proteins. Mass spectrometry can be used for the analysis of phosphorylation quantitative proteomics. In mass spectrometry-based phosphorylation quantitative proteomics research, techniques such as immobilized metal affinity chromatography (IMAC), phospho-specific antibodies, or TiO2 can be used to enrich phosphorylated proteins. During the enrichment of peptide segments, mono-phosphorylated and multi-phosphorylated peptide segments can be stepwise separated, followed by mass spectrometry analysis. Mass spectrometry-based phosphorylation quantitative proteomics research includes both qualitative and quantitative analysis of the phosphoproteome, providing detailed information about the identified phosphorylation sites.
Phosphoproteomics
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