What are the general salt forms of peptides? How to convert salt forms or desalt?
Most peptides are purified in trifluoroacetic acid (TFA) systems, making TFA salts the most common form, followed by acetate and hydrochloride forms. Very few peptide drugs are in special salt forms. Ion exchange and high-performance liquid chromatography (HPLC) are the most commonly used methods for salt conversion, while G25 (a dextran gel column from GE Healthcare) can be used for desalting.
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