Amino Acid Mass Spectrometry

Amino acids are the basic building blocks of proteins. Different types and quantities of amino acids form diverse proteins with various functions through different arrangements. Besides being the fundamental units of proteins, free amino acids and their derivatives are crucial for maintaining the body's homeostasis and balance, playing significant roles in regulating growth and immunity. Studies have shown that abnormal amino acid levels can also cause certain diseases. Furthermore, amino acids can be used as raw materials for health supplements and biopharmaceuticals.

Whether it is for determining the composition of protein amino acids or for manufacturing amino acid supplements or biopharmaceuticals, amino acid identification is indispensable. Amino acid composition identification is the foundation and prerequisite for analyzing the primary structure of proteins and a key indicator to ensure the quality of amino acid health supplements and biopharmaceuticals. Amino acid identification mainly involves determining their types and concentrations. Amino acid mass spectrometry refers to using mass spectrometry technology to analyze amino acids. High-resolution and high-sensitivity mass spectrometry achieves qualitative and quantitative identification by detecting the mass-to-charge ratio and ion peak intensity of amino acids. This method relies on a known theoretical amino acid mass spectrum database, comparing the detected data with the database to determine the amino acid types. Typically, chromatography technology is combined for identification, such as LC-MS and LC-MS/MS.

Biotechnology company Baitai Parker uses Thermo Fisher's Orbitrap Fusion Lumos mass spectrometry platform combined with Nano-LC nanoliter chromatography to provideamino acidmass spectrometry analysisservice packages, enabling quantitative and qualitative analyses of over 70 amino acids and their derivatives. 95% of the substances involved are quantified using standards and isotopic standards to ensure the accuracy of quantitative results. Free consultations are welcome.

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