Ganglioside Analysis

Gangliosides are a large class of complex lipids that are components of the neuronal cell membranes abundantly present in the brain. Gangliosides are molecules composed of sphingolipids linked to one or more sialic acids on the sugar chain. As structural components of cell membranes, their two hydrocarbon chains embed into the plasma membrane, while the oligosaccharide is located on the cell surface, providing recognition points for extracellular substances or surface molecules of adjacent cells. The oligosaccharide group can serve as surface markers, playing a significant role in cell recognition, adhesion, and signal transduction.

GM1 Ganglioside

Gangliosides provide neuroprotection by promoting neural development in newborns and are involved in memory and learning processes, although their mechanisms are not fully understood. Some believe gangliosides protect cells in the extracellular environment from harsh conditions such as low pH and degradative enzymes. They have been shown to facilitate interactions between cells and the extracellular matrix and other cells. Gangliosides are also associated with cancer and Alzheimer's disease. During aging and in certain neurodegenerative diseases, ganglioside distribution patterns change. Significant alterations in ganglioside profiles are observed in Alzheimer's disease, Parkinson's disease, Huntington's disease, HIV1-associated dementia, and lysosomal storage diseases.

Mass spectrometry is extensively used for studying gangliosides. Biotech Company Biotech Pack provides reliable, fast, and cost-effective ganglioside analysis services based on a system with high stability, repeatability, and sensitivity for separation, characterization, identification, and quantitative analysis.

Related Services

Targeted Lipidomics
Untargeted Lipidomics
Lipid Metabolomics Research
Fatty Acids and Fatty Acid Metabolism
Hexosylceramide
Carbohydrates and Carbohydrate Metabolism