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Other Post-Translational Modification Analysis

Post-translational modification refers to various chemical modifications that proteins undergo after translation is complete. Proteins may undergo diverse chemical modifications after synthesis, such as phosphorylation, methylation, acetylation, ubiquitination, etc. These modifications can alter the protein's structure, function, and interactions, thus regulating cellular physiological processes and signal transduction. The goal of post-translational modification analysis is to identify, quantify, and study the types, locations, and impacts of these modifications to gain a deep understanding of the protein's modification state and function, typically involving multiple steps such as protein extraction, proteolytic digestion, modified peptide enrichment, and liquid chromatography-mass spectrometry analysis.

Basic Principles of Post-translational Modification Analysis

Post-translational modification analysis also plays a key role in the characterization of bioproducts. It is an essential component in product quality, functionality, safety, and in the control, validation, and regulation of production processes. It is of significant importance in the design and development of new bioproducts, for example, in developing protein drugs with specific post-translational modifications. BTP, Biotech, has been certified by both CNAS and ISO9001 quality systems. The company has developed a series of post-translational modification characterization methods based on high-resolution mass spectrometry to provide you with precise post-translational modification analysis services. This includes qualitative and quantitative identification of various modifications such as phosphorylation, acetylation, ubiquitination, methylation, oxidation, deamidation, and N/C-terminal variations (N-terminal M retention, C-terminal K deletion). Additionally, we support customized post-translational modification analysis (e.g., ADC drug small molecule binding site analysis).Feel free to contact us for a free consultation to learn more details!

Bilingual Project Report (Chinese/English)

In the technical report, BTP will provide you with a detailed bilingual (Chinese/English) technical report, which includes:

1. Experimental procedures (in Chinese and English)
2. Relevant mass spectrometry parameters (in Chinese and English)
3. Detailed information on post-translational modification analysis
4. Mass spectrometry images
5. Raw data

Post-translational Modification AnalysisOne-stop Service

You only need to place an order and send your samples
BTP's one-stop service completes: sample processing, on-machine analysis, data analysis, and project report