Metabolomics and Transcriptomics Joint Analysis

The transcriptome refers to the complete set of all mRNA transcribed from an organism during specific growth development stages or under different physiological and pathological conditions. According to the central dogma, DNA is transcribed into mRNA and then translated into proteins. In the genetic rule, mRNA holds a central hub position, serving as a bridge linking gene expression to downstream final translation products. Transcriptome analysis is a powerful tool for studying functional genes. By analyzing transcriptomics data, one can obtain a large number of differentially expressed genes and numerous regulatory networks, although it is difficult to determine the key regulatory pathways and the substances controlling these pathways.

The metabolome refers to all endogenous small molecule metabolites produced by an organism during different periods or physiological states. It represents the final result of gene transcription under internal and external regulation and is the basis and direct manifestation of an organism's phenotype. Small changes in gene expression and phenotypic traits can be amplified at the metabolic level. Therefore, metabolomics analysis can reflect the molecular mechanisms of phenotypic changes. Integrating transcriptomics and metabolomics allows for the connection between gene expression and phenotypic changes, dissecting biological issues from both the "cause" and "effect" levels. By screening key genes and metabolites in a particular biological process, one can construct core biological metabolic pathways and regulatory networks, explaining the genetic mechanisms affecting phenotypes and providing a deep and holistic understanding of the growth, development, and pathological processes of biological systems.

Biotech PacBio utilizes Thermo Fisher's Q Exactive HF mass spectrometry platform, Illumina high-throughput sequencing platform, and Nano-LC chromatography to provide reliable, fast, and cost-effective gut microbiome analysis services.Integrated analysis of metabolomics and transcriptomicsService package: You only need to tell us your experimental purpose and send us your samples. We will handle all subsequent project matters, including experimental design, sample testing, and data analysis. We can meet various testing needs. Free consultation is welcome.

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