Urinary Proteomics
Disease biomarkers play a crucial role in disease prevention, diagnosis, treatment, and prognosis. An ideal disease biomarker can provide sensitive and accurate signals in the early stages of disease, helping doctors make timely and effective clinical decisions to ensure patient health. Blood, tissue fluid, and urine are the best clinical biosamples for studying diagnostic biological markers. Compared to other sample proteomics analyses, urine proteomics analysis has the following advantages:
Richness: The urinary proteome contains abundant biological information. As the body fluid closest to the urinary system, part of the urinary proteome originates from the urinary system, while another part comes from plasma filtered through the glomerulus. Therefore, the urinary proteome can reflect the functional state of the urinary system, retain some information about plasma proteins, and to some extent, reflect the state of the blood and the entire body.
•Simplicity: The urinary proteome is not very complex, with a dynamic range of approximately 10^6. The high abundance suppression effect is not as significant as in blood, making it easier to identify low-abundance proteins (potential disease biomarkers).
•Non-invasiveness: Urine can be collected completely non-invasively, continuously, and in large quantities. In contrast, the collection of tissue fluid and blood is usually invasive, often performed at specific time points, and the collection quantity is relatively limited. Using proteins from urine as detection targets makes it easier to detect changes in biological quantities over time.
•Variability: Blood and tissue fluid have strict homeostatic regulation, with change information existing for a shorter time, making it difficult to identify biomarkers. Urine lacks homeostatic regulation, which means it can accumulate a wider variety and greater magnitude of changes. Many changes in the body are likely to be reflected in urine, making it easier to find disease biomarkers.
•Stability: Urine samples can remain stable at -20°C and are suitable for proteomics analysis even after being stored for many years.
Figure 1: Urine protein samples for omics analysis
Biotech company Thermo provides ultra-high-resolution Orbitrap Fusion Lumos mass spectrometry combined with Nano-LC for urine proteomics analysis service packages, including qualitative and quantitative identification of urinary proteins and differential comparison analysis of different urinary proteomes to help identify biological markers. Free consultations are welcome.
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