Peptide Omics Analysis

Peptidomics Analysis

The aim of peptidomics analysis is not only to identify and validate all endogenous peptides in the biological samples under study but also to compare the expression levels of target peptides in specific biochemical processes. With the aid of mass spectrometry, unbiased analysis of target peptides can be achieved.

Peptidomics and proteomics share many similarities in research strategies, but there are some important differences between them. To achieve the identification of native peptides, such as some post-translational modification analyses, specific digestive enzymes are usually not used in peptidomics research. Therefore, primary mass spectrometry (MS) and secondary mass spectrometry (MS/MS) are used for peptide identification.

With the development of MS/MS sequencing technology, MS-based peptide identification has gradually replaced the conventional Edman degradation method. Mass spectrometry is used in many studies to identify peptides in various tissue extracts, such as the analysis and identification of bioactive peptides. By using size-exclusion chromatography to remove most proteins from biological samples, fluids, and tissue extracts, LC-MS can perform peptide identification with high accuracy and reproducibility. Biotech company Biotage can provide customized peptidomics-related analysis services according to customer needs.

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