Exosome Proteomics
Exosome proteomics aims to study the protein composition of exosomes. Mass spectrometry-based methods can be used for exosome proteomics research. Biotech company Biotech Pack provides mass spectrometry-based exosome proteomic analysis services.
Exosome Proteomics
Exosomes are extracellular vesicles encapsulated by a lipid bilayer membrane containing proteins, RNA, and other cellular secretions. They can be secreted by most cells and are present in most body fluids (such as blood, urine, saliva, etc.) and cell culture media. Exosomes have a high protein content, and these proteins have a wide range of functions. Exosome proteomics aims to utilize proteomic techniques to study the proteins in exosomes at a holistic level, thereby aiding in the functional research and clinical applications of exosomes, such as biomarker screening and identification, and drug target discovery.
Exosome Proteomics 1
Exosome Proteomic Analysis
The primary step in conducting proteomic research on exosomes is the isolation and extraction of exosomes. Currently, common methods for exosome extraction include ultracentrifugation, gel filtration, magnetic bead separation, and polymer precipitation, each with its own advantages and disadvantages. Researchers can choose the appropriate method based on actual conditions. Once exosome extraction is completed, techniques such as gel electrophoresis, chromatography, and mass spectrometry can be used to measure the exosome proteome. Among these, the combination of liquid chromatography and mass spectrometry allows for a comprehensive qualitative and quantitative analysis of the exosome proteome.
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